I've been a huge fan of Sierra On-Line games since I was a kid. When I found out that the tools existed to make my own, I pounced on the opportunity. Thus was born Voodoo Girl: Queen of the Darned. If you haven't played any adventure games in a long time, I would advise you to grab a copy of NAGI from http://www.agidev.com/download/ and play some of the old classics, along with a bunch of new generation titles that are available.
Also on that download page are tools for making AGI games. I tried other adventure game platforms, like AGS, but something about the simplicity of AGI really appealed to me.
While a lot of the simplicity was an artifact of the limitations of computers at the time, some of it was good design.
I think that Flash represents a very good platform for adventure games. It has about as rich a set of graphic and animation tools as you could need. All I've done is worked on some bookkeeping infrastructure. For example, one of my goals will be allowing the player to keep save game backups on a host server, so they can play the same game on their lunch break as well as at home.
In any case, I have the single room proof-of-concept that I'm working on available here ->
AS3 AGI version 0